Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders

Article Abstract:

A de novo chromosome 7q inversion disrupting Autism susceptibility candidate 2 (AUTS2) and Contactin Associated Protein-Like 2 (CNTNAP2) in a child with congitive and social delay is identified. It is suggested that rare variants contribute to the pathophysiology of autism spectrum disorders (ASD).

Amino acid sequence, Amino acid sequencing, Autistic children, Human cytogenetics

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Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain

Article Abstract:

FOXP2, the transcriptional factor genes in human brain is identified using chromatin immunoprecipitation followed by microarray analysis (ChIP-chip). The FOXP2-target genes give insights on the vital functions and pathways to explore the genetic basis of human speech and language.

Speech, Brain research, Genetic transcription, Transcription (Genetics), Cognition

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High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders

Article Abstract:

The article examines direct targets regulated by FOXP2 in neurons by high-throughput screening of microarrays. FOXP2 activates or represses gene expression at occupied promoters and helps in neural processes involved in speech and language.

Usage, Polymerase chain reaction, Gene expression, Mutation (Biology), Mutation, Speech disorders

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