Molecular mechanisms for organizing the neuronal cytoskeleton

Article Abstract:

The evidence supporting two leading models of neurofilaments (NF) and microtubules (MT) organization in neurites such as cross-bridging and polymer-brush-based repulsion is reviewed. The side arms of neurofilaments and the projection domains of microtubule-associated proteins are highly unstructured and exert long-range repulsive forces that are largely entropic in axons.

Cytoplasmic filaments

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Molecules versus morphology? Not for the human cranium

Article Abstract:

Natural selection cannot explain similarities between patterns of cranial and molecular diversity observed in humans. The amount of phenotypic variance in the human cranium decreases at the population level as a function of distance from Sub-Saharan Africa much in the same way as observed for human molecular data.

Immunological research, Immunologic research, Molecular evolution, Human genome, Cranial sutures

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From genes to human diseases in cortical development

Article Abstract:

The latest findings and their implications in relation to advances in molecular genetics and the exploration of cerebral cortical development which were discussed at the Novartis Foundation in London is reviewed.

Cerebral cortex

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