More TORC for the gluconeogenic engine

Article Abstract:

An attempt is made to study the transcriptional factor CREB (Camp responsive element binding protein), that controls hormonal regulation of gluconeogenesis, which in turn controls glucose production in liver, and to understand the causes of mortality due to diabetic mellitus. A search for the additional coactivators of CREB has identified a family of TORC proteins (transducer of regulated CREB activity) and their ability to potentiate the activity of wild type mutants as well as phosphorylation defective mutants of CREB.

Analysis, Risk factors, Diabetes, Diabetes mellitus, Phosphorylation, Glucose metabolism, Gluconeogenesis

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A newly discovered founder population: The Roma/Gypsies

Article Abstract:

The Gypsies defy the conventional definition of a population who have no nation-state, speak different languages, belong to many religions and comprise a mosaic of sociality and culturally divergent groups separated by strict rules of endogamy. The population studies, initiated and designed to answer the questions raised by medical genetics, have made a big step forward and characterized the Gypsies as one of the most interesting founder populations and a valuable part of European genetic landscape.

Genetic aspects, Genetic research, Medical genetics, Romanies

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Microbial experiments on adaptive landscapes

Article Abstract:

The landscape generated by plotting fitness against genotypes or phenotypes in microbial evolution experiments using short generation organisms like bacteria or viruses is studied. Results provide insights into the nature of adaptive landscapes and the way in which such landscapes can affect the path of adaptation.

Bacterial genetics, Adaptation (Physiology), Physiological adaptation, Animal locomotion

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