Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa-B/Rel family

Article Abstract:

Development of mutant mice with a relB germline mutation helps analyze the role of RelB in the constitutive expression of kappa-B-regulated lymphoid tissue genes. Myeloid hyperplasia, reduction in dendritic cells that present antigens in the thymus and a multifocal, mixed inflammatory cell infiltration in many organs are some of the lesions observed in RelB-deficient mice. Cellular immunity is also defective in these mice, indicating that RelB is essential for the immune system.

Genetic regulation, Genetic transcription, Transcription (Genetics), Hematopoietic system

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Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation

Article Abstract:

The overexpression of a GPI linked plasma membrane protein, the HA receptor for hyaluronan-mediated motility (RHAMM), is transforming and causes metastatic fibrosarcoma. Dominant negative mutants of the RHAMM disturb its function, resulting in a decrease of the transforming properties of the ras oncogene. The activity of RHAMM is regulated by growth factors and the presence of RHAMM is required for transforming growth factor-beta1 stimulation of fibrosarcoma cell motility.

Metastasis, Cancer metastasis, Cell receptors

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Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement

Article Abstract:

The gene hemipterous (hep) participates in a new mitogen-activated protein kinase kinases pathway and is essential for the morphogenetic activity of the dorsal epidermis. The hep gene is also necessary for the expression of another dorsal closure gene, 'puckered.' Embryogenesis in Drosophila is accompanied by a cell sheet movement, dorsal closure, that sets up the dorsal epidermis. The lateral epithelia move toward the dorsal midline in the morphogenetic process.

Observations, Drosophila, Morphogenesis

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