Multipoint quantitative-trait linkage analysis in general pedigrees

Article Abstract:

Variance-component linkage methods can be applied to multipoint quantitative-trait linkage analysis with pedigrees of any size and complexity. A multipoint identity-by-descent (IBD) method has been developed by extending to general relative pairs the approach to sib-pair multipoint mapping of Fulker et al. The multipoint IBDs for relative pairs can then be used for variance-component linkage analysis of the entire pedigree.

Methods, Linkage (Genetics)

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Pedigrees - publish? or perish the thought?

Article Abstract:

The International Committee of Medical Journal Editors has stated that published photographs and pedigrees should not include identifying information unless it is scientifically justified and consented to by the subject. Although this policy treats photographs and pedigrees as equivalent, the threat posed by pedigrees is less severe than that posed by photographs.

Editorial, Standards, Publishing industry, Periodicals, Medical publishing, Genealogy

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Online system for faster multipoint linkage analysis via parallel execution on thousands of personal computers

Article Abstract:

A distributed system called 'SUPERLINK-ONLINE' is presented for the computation of multipoint LOD scores of large inbred pedigrees. It achieves high performance through the efficient parallelization of the algorithms in SUPERLINK and through the use of the idle cycles of thousands of personal computers.

Research, United States, Computational biology, Pedigree analysis

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