Mycobacterial ecology of the Rio Grande

Article Abstract:

The environmental conditions which contribute to the presence and proliferation of environmental mycobacteria in a major freshwater river is characterized. Environmental mycobacteria could survive in the alkaline conditions of the river despite reports that especially acidic conditions favor their presence.

Environmental aspects, Microbial ecology

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Molecular cloning and expression of genes encoding a novel dioxygenase involved in low- and high-molecular-weight polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1

Article Abstract:

Mycobacterium vanbaalenii PYR-1 is able to metabolic a wide range of low- and high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs). A 20-kDa protein was upregulated in PAH-metabolizing M. vanbaalenii PYR-1 cells compared to control cultures.

Genetic aspects, Gene expression, Cell culture

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Antagonists of Hsp16.3, a low-molecular-weight mycobacterial chaperone and virulence factor, derived from phage-displayed peptide libraries

Article Abstract:

The identification of peptides by phage display that bind to Hsp16.3 protein and inhibit its chaperone activity is reported. The peptide inhibitors of Hsp16.3 obtained could serve as the basis for developing potent drugs against persistent tuberculosis.

Drug therapy, Tuberculosis, Molecular chaperones

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