TATA element recognition by the TATA box-binding protein has been conserved throughout evolution

Article Abstract:

Results demonstrate interaction and formation of Hoogsteen base pairs between TATA box-binding protein (TBP) and TATA elements in the recognition process. Data also point out that TBP-TATA complex is an integral part of the RNA polymerase II transcription machinery and is conserved through the course of evolution.

United States, Statistical Data Included, Research, Carrier proteins, Transport proteins, Enzymes, RNA polymerases, Enzyme structure-activity relationships

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Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

Article Abstract:

The article describes that redundant binding correlates with consensus ETS-binding sequence near transcription start sites and contrary specific binding sites diverged dramatically from the consensus that were found further from transcription sites.

T cells, DNA-ligand interactions, DNA binding

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