Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
Article Abstract:
Different types of cells replicate their chromosomes in S phase and separate them during mitosis and studies were conducted to show that when cells in drosophila wing discs are delayed in G1 they maintain their normal acceleration passage through S and G2. It was found that the compensation mechanism uses negative feedback, in which cyclin-dependant kinases downregulate the transcription factor, which activates the Cdks to propel dive cell progression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
From cell structure to transcription: Hippo forges a new path
Article Abstract:
The cytoskeletal proteins which play a role in cell adhesion and structure, control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats kinase complex. Warts/Mats kinase phosphorylates and inhibits Yorkie, a transcriptional coactivator that positively regulates cell grown, survival and proliferation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Regeneration and transdetermination: New tricks from old cells
Article Abstract:
A longstanding question in regeneration biology regarding the way pluripotency is achieved during regeneration is addressed. The cell cycle and growth characteristics of multipotent regenerating and transdetermining Drosophila cells are examined.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Drosophila Myc regulates organ size by inducing cell competition. The molecular basis of odor coding in the Drosophila antenna
- Abstracts: Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR. Diverse tetracycline resistance genotypes of megasphaera elsdenii strains selectively cultured from swine feces
- Abstracts: Plastic encapsulation of stabilized escherichia coli and psedomonas putida. Addition of aromatic substrates restores trichloroethylene degradation activity in pseudomonas putida F1
- Abstracts: Factors affecting lactate and malate utilization by Selenomonas ruminantium. Specific PCR assay for tannin-tolerant selenomonas ruminantium isolate, derived from helicase coding sequences
- Abstracts: A small modulatory dsRNA specifies the fate of adult neural stem cells. The notch transcription activation complex makes its move