No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus

Article Abstract:

The transcriptional activators that are involved in different cellular pathways and regulating many different genes such as beta-catenin in Wnt signaling and p53 in checkpoint responses, are components of different and multisubunit complexes. Exporting beta-catenin out of nucleus would inhibit the activation of most Wnt target genes, and association of the APC-beta-catenin complexes on chromatin could be limited to a subset of Wnt target genes.

All Other Basic Inorganic Chemical Manufacturing, Industrial inorganic chemicals, not elsewhere classified, Ammonium Perchlorate, Chromatin, Chemical properties

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YY1 helps to bring loose ends together

Article Abstract:

The transcription factor Yin Yang 1 (YY1) binds with immunoglobulin having crucial role in cell cycle control, oncogenesis and X-chromosome inactivation and B cell development. YY1 is found to bring the genes located at two different ends in the close proximity and thus help in recombination.

Carcinogenesis, X chromosome

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Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis

Article Abstract:

The critical role played by Meis1 in leukemias associated with the Mixed Lineage Leukemia (MLL) and in normal hematopoiesis is discussed.

Hematopoietic stem cells, Leukemia, Hematopoiesis

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