Nuk controls pathfinding of commissural axons in the mammalian central nervous system

Article Abstract:

Two mutations in the mouse germline were generated to address the biological functions of the Eph family member Nuk. The two mutations are a protein null allele (Nuk1) and an allele that encodes a Nuk-beta gal fusion receptor whose tyrone kinase and C-terminal domains are absent. Most axons forming the anterior commissure's posterior tract aberrantly migrate to the brain's floor in Nuk1 homozygous brains. This prevents cortical neurons from linking the two temporal lobes. Results demonstrate the role of Nuk in pathfinding specific axons in the mammalian central nervous system.

Physiological aspects, Central nervous system, Axons, Mammals

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Signaling networks - do all roads lead to the same genes?

Article Abstract:

Several studies have been carried out to analyze the ability of individual biochemical pathways activated in the cytoplasm to induce novel, overlapping, or redundant alterations in the pattern of expressed genes. These studies have characterized docking sites for SH2 proteins that confer an element of biological specificity. Several pathways have also been identified through which phosphotyrosine signals can be conveyed to the nucleus.

Analysis, Cellular signal transduction, Gene expression, Cytoplasm

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UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans

Article Abstract:

Research was conducted to characterize the unc-73 gene product from Caenorhabditis elegans as it relates to guided cell and growth cone migrations. Results showed that unc-73 affected several cell migrations in C. elegans and influenced pioneer and non-pioneer growth cone and cell migrations. They also indicated that the unc-73 peptide was capable of activating Rac and inducing actin reorganization characteristic of membrane ruffling.

Genetic aspects, Peptides, Caenorhabditis elegans, Cell physiology

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