Ontogeny of basal and regulated proopiomelanocortin-derived peptide secretion from fetal and neonatal pituitary intermediate lobe cells: melanotrophs exhibit transient glucocorticoid responses during development
Article Abstract:
The basal and corticotropin releasing hormone- and glucocortocoid-regulated secretion of proopiomelanocortin (POMC) by single cells from the intermediate lobe of the pituitary gland of melanotrophs was investigated using reverse hemolytic plaque assay. Basal secretion was first detected at Embryonic Day 17.5 and CRH-regulated secretion was first detected at e19.5. but both secretions were inhibited by dexamethasone (DEX). Inhibition by DEX in melanotrophs was completely absent by postnatal Day 3 but still existed in corticotrophs. Meanwhile, the dopamine agonist ergocryptine inhibited POMC secretion only in melanotrophs, but not in corticotrophs.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1996
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Ontogeny of basal and regulated secretion from POMC cells of the developing anterior lobe of the rat pituitary gland
Article Abstract:
The basal and regulated secretion of proopiomelanocortin (POMC) by single cells from the anterior and intermediate lobes of the adult rat pituitary was investigated using the reverse hemolytic plaque assay. Basal secretion was first observed at Embryonic Day 13.5, when POMC was first detected immunocytochemically while corticotropin releasing hormone (CRH)-regulated secretion was first detected at e15.5, when CRH neurons were first detected immunohistocytochemically in the hypothalamus. CRH-stimulated secretion reached its peak at e16.5, but was inhibited by the presence of dexamethasone.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1996
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Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica
Article Abstract:
A study was conducted to examine the patterns of wound healing and skin development from Pouch Day (PD) 0 to PD 30 compared to adults in opossum Monodelphis domestica. In vivo dermal incisions revealed healing without macroscopic scars if wounded before PD nine, but scarring after this day, while observations on the inflammatory reaction of wounds revealed prominent inflammation after PD nine. These results suggest that healing of fetal wounds depends on inflammatory reaction and skin development in fetal M. domestica.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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