Overproduction of threonine by Saccharomyces cerevisiae mutants resistant to hydroxynorvaline

Article Abstract:

Threonine-excreting mutants of Saccharomyces cerevisiae were isolated by selection of hydroxynorvaline-resistant mutants. The selected strains were able to accumulate 15 to 30 times more threonine and excrete three times more threonine than the wild type. Isoleucine was also overproduced. The mutated allele was shown to be dominant and coded for aspartate kinase, which was totally or partially insensitive to feedback inhibition by threonine. The results suggest that threonine-overproducers can be efficiently isolated in other yeast strains, including the industrially important ones.

Production processes, Mutagenesis, Threonine

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Redirection of the respiro-fermentative flux distribution in Saccharomyces cerevisiae by overexpression of the transcription factor hap4p

Article Abstract:

Overexpression of the transcription factor in Saccharomyces cerevisiae by Hap4p and resulting redirection of the respiro-fermentative flux distribution are discussed. Modification of a minimum of one transcription regulator can be powerful and widely applicable as a tool for redirecting the metabolic fluxes in mcroorganisms.

Netherlands, Genetic aspects, Fermentation, Yeast, Yeast (Food product)

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Internal trehalose protects endocytosis from inhibition by ethanol in Saccharomyces cerevisiae

Article Abstract:

Research demonstrates that the primary factor protecting the endocytosis in yeast from ethanol is trehalose sugar as shown by the correlation between trehalose accumulation and ethanol resistance and mutants deficient in trehalose synthetic capacity lacking resistance to ethanol.

Spain, Research, Sugars, Carbohydrates, Alcohol, Ethanol, Endocytosis, Cell physiology

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