P13K gamma modulates the cardiac response to chronic pressure overload by distinct Kinase-dependent and independent effects

Article Abstract:

The G protein coupled, receptors-activated phosphoinositide 3-kinase gamma(PI3K gamma) mediates inflammatory responses and negatively controls cardiac contractility by reducing cAMP concentrations. A study is conducted to show that mice carrying a targeted mutation in the PI3K gamma gene causing loss of kinase activity (PI3K gamma(super KD/KD)) display reduced inflammatory reactions but no alterations in cardiac contractility.

Cyclic adenylic acid, Cyclic adenosine monophosphate, Phosphoinositides, Phosphatidylinositols

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Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development

Article Abstract:

RPM-1 that negatively regulates a p38 MAP kinase pathway composed of the dual leucine zipper-bearing MAPKKK DLK-1, the MAPKK MKK-4, and the p38 MAP kinase PMK-3, is reported. A presynaptic role of a previously unknown p38 MAP kinase cascade is revealed.

Genetic regulation, Ubiquitin

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PKR and elF2alpha: Integration of kinase dimerization, activation and substrate docking

Article Abstract:

The interaction between PKR and elF2alpha is addressed. The structures of elF2alpha bound to PKR reveal that PKR forms a dimer, the interface, which is essential for kinase activation, and demonstrate how this protein substrate docks to its kinase.

Genetic research

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