Pathways of intracellular communication: tetrapyrroles and plastid-to-nucleus signaling

Article Abstract:

This article discusses the role of plastid-to-nucleus signals in the nuclear and plastid gene expression as exemplified by tetrapyrroles, which are components/products of photosynthetic metabolism. Research reveals that magnesium-protoporphyrin functions as a plastid signal for the repression of nuclear photosynthetic gene transcription as shown in genomes uncoupled mutants of Arabidopsis.

Influence, Genetic aspects, Gene expression, Genetic transcription, Transcription (Genetics), Pyrroles

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Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM proein kinase

Article Abstract:

This article examines the mechanism by which ATM protein kinase responds to damaged DNA in the light of the finding, which states that DNA-strand breaks trigger activaion of ATM kinase through chromatin structural changes. A checkpoint model suggests that chromatin perturbations cause conversion of inactive ATM domains tp phosphorylated, active ATM monomers.

DNA damage, Epigenesis

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LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways

Article Abstract:

Research shows that a multichain receptor, the pre- or the T-cell antigen receptor, activates protein tyrosine kinases, which is linked to distal signaling pathways through the linker for activation of T cells (LAT). structure-function analysis of LAT indicate that LAT mediated pathways are integrated at the level of the LAT adapter.

Analysis, Antigen receptors, T cell, T cell antigen receptors, T cells

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