Pdm and castor specify late-born motor neuron identity in the NB7-1 lineage

Article Abstract:

A demonstration that Pdm and Cas regulate late-born motor neuron identity within the NB7-1 lineage, Pdm specifies fourth-born U4 motor neuron identity, while Pdm/Cas together specify fifth-born U5 motor neuron identity is presented. It is concluded that Pdm and Cas specify late-born neuronal identity, that Pdm and Cas act combinatorially to specify a temporal identity distinct from either protein alone and that repression of pdm expression regulates the generation of neuronal diversity.

Oregon, Usage, Neurons, Biological markers

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An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion

Article Abstract:

The identification of NijA, a transmembrane protein whose vertebrate homologs regulate cell adhesion, as a two-hybrid binding partner of Mmp1 is reported. Data indicate that Mmp1 releases the N-terminal extracellular domain of NijA and this liberated ectodomain promotes the loss of cell adhesion in a cell-nonautonomous manner.

Membrane proteins, Cell adhesion, Metalloproteins, Homeostasis, Structure

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The C-terminal tail of the Hedgehog receptor patched regulates both localization and turnover

Article Abstract:

The functional and structural properties of Drosophila patched (Ptc) and its C-terminal domain (CTD), 183 residues that a predicted to reside in the cytoplasm is investigated. The results show that Ptc, as well as truncated Ptc deleted of its CTD, forms a stable trimer.

Protein research, Hedgehogs, Western immunoblotting, Western blot

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