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Planar cell polarity signaling in vertebrates

Article Abstract:

The morphological development of the mammalian organ of Corti is described for the interpretation of the emerging data and the molecular mechanisms are proposed for the underlying planar cell polarity (PCP) signaling in vertebrates. The analysis has shown that the organ of Corti has emerged as an excellent model system to illustrate the multiple cellular processes controlled by vertebrate PCP signaling.

Author: Ping Chen, Jones, Chonnettia
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2007
Vertebrates, Polarity (Biology)

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The molecular basis of neurosensory cell formation in ear development: A blueprint for hair cell and sensory neuron regeneration?

Article Abstract:

The molecular basis of neurosensory development in the mouse ear is explored to provide a blueprint for possible enhancement of therapeutically useful transformation of stem cells into lost neurosensory cells. The use of stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear might help in the neurosensory regeneration of mammalian ears.

Author: Fritzsch, Bernd, Hansen, Laura A., Beisel, Kirk W.
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
Physiological aspects, Nervous system, Nerve regeneration, Stem cells, Ear

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Development and maintenance of ear innervation and function: lessons from mutations in mouse and man

Article Abstract:

Mouse mutations that bring developmental ear defects and those that affect the formation or maintenance of sensory neurons in the hearing or vestibular systems are discussed as are several human genes from which molecular analysis of hearing disorders can proceed. It is argued that the ear is a system with unique advantages for study of developing sensory systems.

Author: Fritzsch, Bernd, Beisel, Kirk
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
Research, Hearing, Cell differentiation, Genetic disorders, Developmental neurology, Senses and sensation, Senses

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Subjects list: United States, Genetic aspects
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