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Ponce d'elegans: genetic quest for the fountain of youth

Article Abstract:

The role of genes in controlling the aging process has been evident in some experiments. Single-site mutations that change some aspects of aging have been discovered. Mutation of the SIR4 gene of yeast lengthened its life span by deactivating a gene responsible for senescence. Mutation of the age1 gene of Caenorhabditis elegans increased its life span by 60%. The daf-2, daf-23 and clk genes have also been found to increase C. elegans' life span.

Author: Kenyon, Cynthia
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
Yeast, Yeast (Food product)

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Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

Article Abstract:

Research examines the interaction of several tissues specify the lifespan of the animal. The tissues act as signaling centers and the transcription factor DAF-16 may regulate two types of downstream signals. Data suggest such tissue interactions and feedback regulation allow the tissues fine-tune the expression of downstream genes, which coordinaes the rate of aging within the animal.

Author: Kenyon, Cynthia, Libina, Nataliya, Berman, Jennifer R.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
United States, Science & research, Research, Analysis, Physiological aspects, Gene expression, Life spans (Biology), Life span (Biology), Endocrinology

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Subjects list: Aging, Genetic aspects, Caenorhabditis elegans
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