Pre-mRNA processing and the CTD of RNA polymerase II: the tail that wags the dog?

Article Abstract:

The carboxy-terminal domain (CTD) of RNA polymerase II was characterized as an activating component of transcription that mediated the processing of RNA. The RNA polymerase II CTD also releases spliceosomes that mediate the catalytic steps of splicing and splicing substrate synthesis which were vital for the messenger RNA processing machinery. Furthermore, the RAN polymerase II CTD acted as a target for the control of transcriptional elongation.

RNA splicing

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Allosteric binding of nucleoside triphosphates to RNA polymerase regulates transcription elongation

Article Abstract:

Research reveals that Escherichia coli RNA polymerase possessess an allosteric binding site to which templated nucleotide triphosphate binds. Results indicate that RNA polymerase exists in two states that catalyze slow and fast synthesis, the latter being influenced by binding of the templated nuclotide triphosphate to the allosteric site.

United States, Analysis, Binding sites (Biochemistry), Active sites (Biochemistry), Allosteric enzymes

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TATA binding protein-associated CK2 transduces DNA damage signals to the RNA polymerase III transcriptional machinery

Article Abstract:

The regulation of protein kinase CK2 with reference to its function in polymerase III transcription shows that CK2 associates with TFIIIB and transduces signal from DNA damage sensors to TATA binding protein. Data point out that CK2 is the terminal effector repressing polymerase III transcription during genome integrity compromization.

Canada, Cellular signal transduction, Protein kinases

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