Prevalence of dopamine and 5HT2C receptor polymorphisms in Amerindians and in an urban population from Argentina

Article Abstract:

The frequency of DRD2A1, DRD3A1, DRD4/2R-10R and 5HT2C-A1 variants in the population of the city of La Plata, Argentina, and in Amerindians from Argentina, Paraguay and Chile is reported. The analysis has suggested that the ethnic variations in the prevalence of the allelic forms of these genes might be a confounding factor to be taken into consideration in studies of association between dopaminergic and serotonergic receptor genotypes and neuropsychiatric and mood disorders.

Argentina, Causes of, Demographic aspects, Genetic polymorphisms, Ethnic groups, Allelomorphism, Alleles, Prevalence studies (Epidemiology)

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Renin, ANP, ACE polymorphisms, blood pressure and age in American Samoans: preliminary data

Article Abstract:

The effects of renin, atrial natriuretic peptide (ANP) and angiotensin-converting enzyme (ACE) on blood pressure were analyzed for American Samoans. Although ANP and ACE produced significant differences in systolic or diastolic hypertension frequencies, renin elevated systolic pressure in certain groups. These tests were conducted using gene and genotype frequencies for each of the three loci.

Health aspects, Blood pressure, Angiotensin converting enzyme, Natriuretic peptides, American Samoa, Renin

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Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations

Article Abstract:

The Indian population shows presence of a polymorphic allele for alcohol dehydrogenase involved in the metabolism of ethanol to acetaldehyde. These alleles present in the noncoding region of the ADH genes are functionally correlated with a strong linkage disequilibrium (LD) block in all the populations.

Science & research, Indians (Asian people), Alcohol dehydrogenase, Alcohol dehydrogenases, Indians, Single nucleotide polymorphisms

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