Principles of viral pathogenesis

Article Abstract:

Viral pathogenesis covers the functions through which a virus causes disease and the host resists or is susceptible. Little data have been acquired on the determinants that control viral virulence of host susceptibility in the natural host. The limited evidence suggests that viruses persist by impairing either antigen presentation or cytotoxic T lymphocyte recognition. They also indicate the possibility of manipulating viral genes in vivo and in vitro to find out those that influence specific diseases and how they produce their effects.

Virulence (Microbiology), Pathogenic microorganisms

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Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development

Article Abstract:

Studies have documented an association between the development of colonic polyps and retinal lesion and adenomatous polyposis coli (APC) tumor suppressor gene mutations in humans. However, the underlying mechanism behind this association remains uncertain. Thus, a genetic study was undertaken to determine APC function in the Drosophila. Results suggest that APC function may be conserved in eye development. In addition, APC was implicated, along with its homolog beta-catenin, as regulators of cell differentiation as well as apoptosis.

Cell death, Retinal diseases, Drosophila, Tumor suppressor genes, Polyposis, Familial, Familial polyposis

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Virology in the next millennium

Article Abstract:

The future of virology is discussed. Gene therapy will be dependent on the development of viral vectors. Recombinant and mutant viruses will be used in vaccines and gene replacement therapy. They will be used for selective killing of tumor cells. The viruses responsible for influenza epidemics might be the most important emerging and evolving one in the future because of demographic factors, with people over the age of 60 making up a greater proportion of the populations of many countries and more people in urban areas.

United States, World, Usage, Demographic aspects, Influenza, 21st century AD, Viral research, Viruses, Virus research, Genetic vectors

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