Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p

Article Abstract:

Progression of meiotic DNA replication in Saccharomyces cerevisiae has been found to be affected by interchromosomal interaction proteins. It is influenced negatively by Spo11p and positively by Rec8p. Effects of mutations in the SPO11 gene were analyzed. Spo11 protein is the catalytic subunit of the meiotic double-strand break transesterase. Effects of deleting the REC8 gene were then studied.

Physiological aspects, DNA, Cytochemistry

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Regulating the formation of DNA double-strand breaks in meiosis

Article Abstract:

Double-strand breaks (DSBs) formation in meiosis is restricted to a narrow window of time for proper execution of the functions of recombination and to prevent production of toxic DNA lesions at appropriate times. Proper timing of these DSB mechanisms are explained in detail providing insights in the poor understanding of DSBs formation.

Science & research, DNA damage, Genetic recombination

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Somatic pairing of homologs in budding yeast: existence and modulation

Article Abstract:

Homologs are paired in vegetatively growing budding yeast diploid cells through multiple interstitial interactions independent of recA homologs and mating type heterozygosity. Whether or not a cell disrupts pairing contacts may be determined by functional considerations that involve homolog/sister discrimination. Somatic pairing of homologs has been studied in budding yeast, Saccharomyces cerevisiae, using fluorescence in situ hybridization (FISH) analysis. Modulation of pairing status in several situations has been investigated. Somatic pairing is qualitatively analogous to premeiotic and early meiotic pairing. S-phase pairing disruption is the result of a complex program in the nucleus that involves regional determinants throughout the nucleus and temporal determinants.

Usage, In situ hybridization, Cell cycle, Homology (Biology), Chromosomes

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