Promoter cleavage: A Topollbeta and PARP-1 collaboration

Article Abstract:

The estrogen-dependent restructuring and transcription of the pS2 promoter requires the generation of a DNA double-strand break by a novel protein complex containing two enzymes, TopoIIbeta and PARP-1. The enzymes topoisomerase IIbeta (Topollbeta) and poly(ADP-ribose) polymerase (PARP-1) have collaborated in a way that alters the molecular composition and structure of the pS2 promoter during an estradiol (E2)-dependent transcriptional response.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Estrogen & Progestogen Preps, Estrogen, Estrogens, Estradiol, RNA interference

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NAD+- dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1

Article Abstract:

The nucleosome binding properties of PARP, which is the most abundantly expressed member of the protein family that catalyze the transfer of ADP-ribose units from NAD+ to specific target proteins, are discussed. The auto modification activity of PARP-1 is stimulated by nucleosomes, which release PARP-1 from chromatin, and the NAD+- dependent activities of PARP-1 are reversed by PARG and are inhibited by ATP in vivo.

NAD (Coenzyme), Nicotinamide adenine dinucleotide, Nucleosomes

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PARP goes transcription

Article Abstract:

This review examines the role of poly(ADP-ribose)polymerase in the modulation of both chromatin structure and transcription in vivo. Authors discuss poly(ADP-ribose)polymerase-1 structure, funtion, and activity, regulaion of its catalytic activity, chromatin structure and transcription, nucleosomes, genetic enhancers and promoters, and gene expression.

United States, Analysis, Physiological aspects, Genetic aspects, Enzymes, Genetic regulation, Gene expression, Genetic transcription, Transcription (Genetics), Enzyme structure-activity relationships, Enzyme regulation, Structure

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