Protein secretion in Bacillus species

Article Abstract:

Bacillus species has been used in industry because it is nonpathogenic and is capable of producing a large amount of secretory proteins. However, little is known of its secretory mechanism. The production of secretory proteins was found to be dependent on various factors: the secreted proteases, the presence of chaperones, the structure of the signal peptide and the signal peptide-matuyre protein junction, the presence of a feedback regulation and the barrier provided by the cell wall.

Bacillus (Bacteria), Bacillus, Secretion, Physiological regulation, Biological transport

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The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis

Article Abstract:

Among the proteins secreted by the Mycobacterium tuberculosis and isolated for gene coding, the proteins of antigen 85 complex, labelled as 85A, 85B, and 85C, were found to be the most common. The 3 were encoded by 3 genes from various sites in the mycobacterium genome and shown to have extensive cross-reactivity and biochemical homology, though differing in molecular mass. The secreted mycobacterial antigens may be significant in the development of immunity and clinical symptoms.

Analysis, Mycobacterium tuberculosis, Antigens

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Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion

Article Abstract:

The action of human enteric bacterial toxin has been tested on intestinal mucosa and intestinal epithelial cells. Diarrhea is believed to be caused by several toxin-producing enteric bacteria whose toxin stimulates intestinal epithelial secretion. Toxins are classified under three types according to the damage done to intestinal cells. A number of enteric bacteria are identified with their corresponding toxin/toxins.

Bacterial toxins, Gastrointestinal diseases, Microbial toxins

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