RNAi components are required for nuclear clustering of Polycomb group response elements

Article Abstract:

Components of the RNA interference (RNAi) machinery are involved in the production of small RNAs at transgenic Fab-7 copies. Dicer-2, PIWI, and Argonaute1, three RNAi components, frequently colocalize with Drosophila Polycomb group bodies and their mutation significantly reduces the frequency of PcG-dependent chromosomal associations of endogenous homeotic genes, suggesting a novel role for the RNAi machinery in regulating the nuclear organization of PcG chromatin targets.

Gene mutations, Gene mutation, RNA interference

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Polycomb group-dependent Cyclin A repression in Drosophila

Article Abstract:

A study is conducted to find out whether Drosophila cell cycle genes are directly regulated by polycomb group (PcG) proteins through PcG response elements (PREs). The results show that Cyclin A is directly regulated by PcG proteins, linking them to cell cycle control in vivo.

Cell cycle

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Inheritance of polycomb-dependent chromosomal interactions in Drosophila

Article Abstract:

Results indicate that the cellular memory module regulating the homeotic gene Abdominal-B in Drosophila, Fab-7, can mediate long-distance interchromosomal interactions, which are heritable through mitotic and meiotic cell division.

France, Analysis, Genetic regulation, Cell nuclei, Cell nucleus, Chromosomes, Structure

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