Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance

Article Abstract:

The Lactobacillus acidophilus NCFM complete genome sequence and selected four open reading frames with similarities to genes involved with decarboxylation reactions involved in acid tolerance in several microorganisms is analyzed. Each integrant exhibited an adaptive acid response during logarithmic growth, indicating that multiple mechanisms are present and orchestrated in L. acidophilus in response to acid challenge.

Nucleotide sequence, Base sequence, Quantitative trait loci

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Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus

Article Abstract:

The histidine protein kinase of a two-component regulatory system, similar to the acid-related system lisRK from Listeria monocytogenes is insertionally inactivated. Two-component regulatory systems are one primary mechanism for environmental sensing and signal transduction.

Analysis, DNA microarrays, Transduction, Transduction (Genetics)

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