Re-evaluating AKT regulation: Role of TOR complex 2 in tissue growth

Article Abstract:

A study focuses on the importance of phosphatidylinositol-3-kinase (PI3k)/AKT signaling in treating cancers, wherein enzymatic activity of AKT is shown to be dependent on phosphorylation of conserved sites by TOR (target of rapamycin) complex 2 (TORC2) in a Pl3K-dependent manner. Experiments show that TORC 2 acts as a rheostat to broaden the range of AKT signaling for tissue growth and metabolism.

Germany, Health aspects, Analysis, Phosphorylation, Rapamycin, Structure, Phosphatidylinositol, Phosphatidylinositols

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Extending the repertoire of the mixed-lineage leukemia gene MLL in the leukemogenesis

Article Abstract:

The molecular and animal models of mixed-lineage leukemia gene (MLL) derived leukemia will exemplify how MLL fusions contribute to leukemia. They are further aimed at developing new therapies for prevalent cancers.

Cancer cells

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Oncogene addiction: setting the stage for molecularly targeted cancer therapy

Article Abstract:

Evidence proving that oncogene addiction plays a major role in the sustained survival and proliferative capacity of many if not all tumor cells is presented.

Tumor suppressor genes, Oncogenes, Tumour suppressor genes

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