Recombinant neuromuscular synapses

Article Abstract:

The molecular mechanisms of nerve-induced high density aggregation of acetylcholine receptors (AChRs) beneath the motor nerve terminal remain to be elicited. Understanding of nerve and muscle interaction in the regulation AChRs in postsynaptic membrane development is still incomplete. Recently, studies on recombinant AChR and 43-kd protein (43k) in non-muscle cells indicate that a distinct domain in the 43k primary structure associate with the cytoplasmic face of the plasma membranes and immobilize AChRs.

Research, Synapses, Neuromuscular junction

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Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle

Article Abstract:

A model describing the role of the ligand AChR-inducing activity (ARIA)/heregulin and erbB kinases as nerve-derived signaling molecules for the transcriptional activation of synaptic nuclei was tested by determining the expression and distribution of ARIA and erbB kinases in developing, adult, mutant muscle. The results showed that ARIA interacts with erbB kinases to provide a signal that induces synaptic expression of AChR genes.

Muscles, Neural transmission, Synaptic transmission

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Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans

Article Abstract:

The Caenorhabditis elegans genome analysis reveals an extensive and diverse nicotinic acetylcholine receptor gene families consisiting of 27 subunits or more. Results indicate that the the receptor binding site motiffs display variations, suggesting some functional specialization. Furthermore, some receptor subunits are preferentially found in neurons, while others are seen in both neurons and muscles.

United Kingdom, Analysis, Genetic aspects, Genomes, Caenorhabditis elegans, Structure-activity relationships (Biochemistry), Structure

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