Recombination suppression by heterozygous Robertsonian chromosomes in the mouse

Article Abstract:

Robertsonian chromosomes are metacentric chromosomes that form by linkage of the centromere ends of telocentric chromosomes. Recombination suppression by heterozygous Robertsonian chromosomes in the mouse showed that mechanical interference in meiotic pairing between Robertsonian chromosomes and their telocentric partners result in suppression ofRobertsonian chromosome formation. Moreover, control linkage studies using C-band markers for the centromeric region showed improved estimates for the centromere-to-first-locus dustance in mouse chromosomes 1, 2 and 16.

Mice, Mice (Rodents)

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An examination of the effects of double-strand breaks on extrachromosomal recombination in mammalian cells

Article Abstract:

A study was conducted to examine the effects of double-strand breaks on intramolecular extrachromosomal homologous recombination in mammalian cells. Defective herpes thymidine kinase (tk) sequence pairs were integrated into mouse Ltk-cells. These cells were set on a DNA molecule which also had a neo gene influenced by the SV40 early promoter/enhancer. Results show that the breaks had an indirect effect on recombination. The results support findings that a pathway for extrachromosomal homologous recombination exists for mammalian cells.

Recombinant DNA, Extrachromosomal DNA

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The relapsing fever agent Borrelia hermsii has multiple copies of its chromosome and linear plasmids

Article Abstract:

The recombination of the variable major protein (Vmp) gene (vmp) in Borrelia hermsii was characterized by investigating the number of copies of the spirochete's chormosome and two linear plasmids. Borrelia can undergo serotype switching to elude the host's immune system. This is done by organizing complete genomes out of the DNA present in the cell. Serotype switching is then accomplished by coexpression of Vmp, suppression of transcription or partition expression of vmp in the different plasmids.

Borrelia

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