Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Article Abstract:

Cyclin D1 is within a cell cycle control node that is deregulated in most human cancers. Studies with mice that lack cyclin D1 show that it is not needed for normal mouse development. It is not needed for cell growth in culture, either. Thus it seems ras-mediated tumorigenesis is dependent on signaling pathways that prefer to act via cyclin D1. There is a drop of up to 80% in development of squamous tumors from grafting or two-stage carcinogenesis.

Genetic aspects, Cell cycle, Keratinocytes, Carcinogenesis

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Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

Article Abstract:

The prospective and clonal isolation of neural rosette cells (R-NSCs) is discussed. Findings reveal a functionally distinct early neural stem cell stage capable of generating the full cellular diversity in the mammalian nervous system.

Nervous system, Gene expression, Structure, Embryonic stem cells

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis

Article Abstract:

The synthesis of cytokine IL6 induced by Ras gene is necessary for the oncogenic activity of Ras.

Analysis, Cytokines, Genetic research, Ras genes

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