Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

Article Abstract:

Regulation by the let-7 microRNAs (miRNA) in Caenorhabditis elegans leads to degradation of its lin-41 target mRNA, despite the fact that its 3'unrelated regions (UTR) regulatory sequences can only partially base pair with the miRNA. The results reveal that mRNAs containing partial miRNA complementary sites can be targeted for degradation in vivo, raising the possibility that regulation at the level of mRNA stability may be common than previously appreciated for the miRNA pathway.

Genetic aspects, Caenorhabditis elegans, Messenger RNA, Genetic research

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New histone incorporation marks sites of UV repair in human cells

Article Abstract:

An approach to follow new histone deposition upon ultraviolet (UV) irradiation in human cells is devised. It is shown that new H3.1 histones get incorporated in vivo at repair sites and it is concluded that chromatin restoration after damage cannot rely simply on histone recycling.

Histones, DNA damage, Structure, Report

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The nucleosome: from genomic organization to genomic regulation

Article Abstract:

The conserved protein structures that mobilize and remodel nucleosomes and specifically mark and recognize their histone and DNA components are described. The impact of nucleosomes on DNA transcriptions, replication, recombination and repair is studied.

Nucleosomes

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