Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase

Article Abstract:

Regulation of hormone-induced histone hyperacetylation and gene activation is discussed. The regulation is effected through acetylation of an acetylase. Nuclear receptors have been thought to regulate gene expression through association with deacetylase complexes or histone acetylase (HAT). The hormone brings on dramatic hyperacetylation at endogenous target genes through the HAT activity of p300/CBP. The hyperacetylation is transient and it coincides with attenuation of hormone-induced gene activation. It was found, in looking at the underlying mechanism, that the acetylase ACTR can be acetylated by p300/CBP.

United States, Research, Histones, Chromatin, Hormones, Genetic regulation

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Circadian clocks: running on redox

Article Abstract:

The intracellular molecular mechanism of circadian rhythmicity is described in terms of clock gene expression in the hypothalamic suprachiasmatic nucleus as influenced by redox reactions. Data indicate that light induces similar redox states in plants as well. Taken together, the rhythmic cellular processes triggered by redox reactions formulate the circadian clock mechanism.

Circadian rhythms, Oxidation-reduction reaction, Oxidation-reduction reactions

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Communication by touch: role of cellular extensions in complex animals

Article Abstract:

This article examines the role of cellular extensions and intercellular networks, created by cells and neurons, in animal systems. Research indicates that they may be involved in the precise formation of binary connections in cells and coupling signaling process with physical force.

Analysis, Cellular control mechanisms, Cell regulation, Neurons, Cell interaction, Cell interactions, Animal development

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