Regulation of organelle biogenesis

Article Abstract:

The development of organelles in eukaryotic cells is regulated at the level of transcription by the genes encoding organellar proteins. Experiments on the yeast, Saccharomyces cerevisiae, have provided much insight into this event and have shown that organogenesis proceeds via a targeting pathway that delivers proteins to the appropriate organelle. There is more than one targeting pathway to every organelle and recent studies on multiple targeting pathways suggest that these pathways may play direct regulatory roles in organelle biogenesis. Regulation is achieved either through intracellular signaling pathways or by transcriptional activation.

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Organelle inheritance

Article Abstract:

Cell organelles in eukaryotic cells give rise to daughter cells that have exactly the same copy number, size and function through a process called inheritance. Organelle inheritance varies for different cell types and for different organisms. There are two organelle inheritance strategies. Stochastic inheritance relies on a cytokinetic mechanism of partitioning and occurs in organelles that are present in multiple copies in the cell cytoplasm. The ordered inheritance strategy relies on the mitotic spindle as the means of partitioning. Both strategies are cell cycle-regulated.

Cell division

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Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor

Article Abstract:

Molecular cloning of cDNAs encoding Xenopus and human proteins revealed Xenopus p100 protein (100 kDA) as a component of DNA replication licensing factor. The protein was bound to the sperm DNA only in thee nuclear phase of the cell cycle, indicating its role in replication licensing. A group of proteins in HeLa cells was observed to exhibit a behavior similar to that of the Xenopus protein during the cell cycle, suggesting that Xenopus and human proteins are homologous.

Research, Cell cycle, Xenopus

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