Rejuvenating exhausted T cells during chronic viral infection

Article Abstract:

The unregulation of the immunoreceptor programmed cell death 1(PD-1) by exhausted T cells during the chronic phase of viral infection in mice is discussed. T cells can be reactivated and the viral load can be reduced by blocking the interaction between programmed cell death-1 (PD-1) and its ligand PD-L1.

Health aspects, Prevention, Physiological aspects, Cell death, T cells, Rats, Rattus, Viral meningitis

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Instruction of distinct CD4 T helper cell fates by different Notch ligands on antigen-presenting cells

Article Abstract:

Immune responses to microbial encounters are tailored by Antigen-presenting cells (APC) to stimulate differentiation of CD4 T cells into the T helper1 (Th1) and T helper2 (Th2) lineages. The APC that uses the Notch pathway to instruct T cell differentiation is demonstrated.

Cell differentiation, Antigen presenting cells, Genetic research

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The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

Article Abstract:

The operation of cell lineages' equilibrium in mammary epithelium at the time of gestation by the basic Notch/RBP-J signaling pathway is discussed.

United States, Research and Development in the Physical, Engineering, and Life Sciences, Cellular Biology, Pregnancy, Cytology, Mammals

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