Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK

Article Abstract:

Kss1, a mitogen-activated protein kinase (MAPK), has a double role in regulating filamentous, or invasive, growth of Saccharomyces cerevisiae yeast. The mechanism for the inhibiting of the invasive growth and how Ste7 function overcomes it have been examined. Unphosphorylated Kss1 binds to the transcription factor Ste12 directly. The binding is required for Kss1-mediated Ste12 repression. The stimulation function that Kss1 has requires its catalytic activity and activation by ste7, a MAPK/ERK kinase (MEK). Ste7-mediated phosphorylation of Kss1 cuts back on Kss1-Ste12 interaction; it also relieves Kss1-mediated repression. The Kss1 activation loop regulates binding to Ste12.

Genetic regulation, Genetic transcription, Transcription (Genetics), Cell differentiation, Mitogens, Developmental cytology

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The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae

Article Abstract:

Cross-activation of mitogen-activated protein kinase (MAPK) cascades, or cross-talk, is restricted in Saccharomyces cerevisiae, but the mechanism is not known. In an effort to identify the mechanism, mutants in which the pheromone response pathway is set off by high osmolarity have been studied. It appears that the Hog1 MAPK interferes with cross-talk between the pheromone response and HOG MAPK pathways.

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Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim 15p protein kinase

Article Abstract:

The protein kinase Rim15p of Saccharomyces cerevisiae is known to be a stimulator of meiotic gene expression. Loss of Rim15p brings an additional pleiotropic phenotype in cells grown on rich medium to stationary phase. cAMP-dependent protein kinase of S. cerevisiae regulates entry to stationary phase with a mechanism involving the Rim 15p protein kinase.

Research, Saccharomyces, Meiosis

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