Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae

Article Abstract:

The peripheral nerve predilection of Mycobacterium leprae, responsible for leprosy, has been studied with attention to the role of the cell wall phenolic glycolipid-1. Evidence for the involvement of the specific trisaccharide unit of the phenolic glycolipid-1 (PGL-1) predilection is offered. PGL-1 binds to the native laminin-2 in the basal lamina of Schwann cell-axon units specifically.

United States, Statistical Data Included, Glycolipids, Axons, Cells, Cell permeability, Leprosy, Peripheral nerve diseases, Peripheral nervous system diseases, Schwann cells, Mycobacterium leprae, Laminin, Tropisms, Tropism

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A common core RNP structure shared between the small nucleolar box C/D RNPs and the spliceosomal U4 snRNP

Article Abstract:

A common core RNP structure has been found to be shared by the spliceosomal U4 snRNP and the small nucleolar box C/D RNPs. The box CD motif binds Snu13p/15.5kD in vitro. It may be that the U4 snRNP (chaperone for U6) and the box CD snoRNPOs have evolved from a common ancestral RNP.

France, Ribosomal RNA, RNA, Binding sites (Biochemistry), Active sites (Biochemistry), Methylation

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The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion

Article Abstract:

The crystal structure of the ligand-binding module of axonin-1/TAG-1 is discussed. It has been found to imply a zipper mechanism for neural cell adhesion. The ligand binding fragment takes in the first four immunoglobulin domains.

Switzerland, Neurons, Cell adhesion, Molecular genetics

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