Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

Article Abstract:

Vascular network formation is regulated by specific ephrinB ligands and EphB receptors. Mice embryos lacking these components die in utero due to remodeling defects in their vascular systems. EphrinB ligand interaction on arteries and EphB receptor on veins indicate important roles in the definition of arterial and venous boundaries and domains.

United States, Cardiovascular system, Circulatory system, Ligands (Biochemistry), Cardiovascular receptors

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PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature

Article Abstract:

The role of PDZ interaction site in ephrinB2 for remodeling of lymphatic vasculature is studied. The results indicate that ephrinB2 is an important regulator of lymphatic development and the interactions of PDZ domain effectors are crucial for mediating its functions.

Science & research, Membrane proteins, Lymphatic vessels

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The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration

Article Abstract:

Results show that vascular morphogenesis in the vertebrate embryo is mediated by the transmembrane ligand ephrinB2 and its Eph receptor tyrosine kinase. Data indicate that ephrinB carboxy terminus is involved in the embryo morphogenesis.

Vertebrates, Embryology, Animal embryology, Vascular endothelium

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