Ro's role in RNA reconnaissance
Article Abstract:
A brief description on crystal structures of Ro alone and bound to both double- and single-stranded RNA, revealing two distinct RNA binding sites that suggest how Ro might distinguish between native and misfolded small RNAs is presented. Ro was originally described over twenty years ago as a major autoantigen in patients suffering from lupus erythematosus.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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The timing of developmental transitions in plants
Article Abstract:
A discussion is presented regarding how RNA silencing mechanisms may influence the juvenile-to-adult vegetative switch. The discovery and regulation of a component of 'florigen' the mobile flowering promotional signal that is involved in the transition to flowering are described.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Structural insights into RNA quality control: The Ro autoantigen binds misfolded RNAs via its central cavity
Article Abstract:
Structures of unliganded Ro and Ro complexed with two RNAs at 1.95 and 2.2 angstrom resolution, respectively are presented. Mutagenesis supports a binding site for misfolded RNAs that encompass both sites, with a single-stranded end inserted into the toroid cavity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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