Rostral cerebellar malformation, (rcm): a new recessive mutation on chromosome 3 of the mouse

Article Abstract:

A new recessive mutation called rostral cerebellar malformation is described in mice. The gene responsible is recessive and was designated rcm. Linkage analysis revealed that the rcm gene is located on chromosome 3. Affected mice have a forward gait that is interrupted every few steps by a swaying motion from side to side. Mutant mice which survive weaning live a normal life span. Histologic changes are of two types. The severe type is confined to the parafloccular lobe of the cerebellum with disruption of the normal layering of the cortex. The focal lesion is spread over the cerebellum and shows molecular cell intrusion into the granular layer.

Cerebellum

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Juvenile bare: a new hair loss mutation on chromosome 7 of the mouse

Article Abstract:

Juvenile bare (jb), a juvenile hair loss mutant in the mouse, is situated on chromosome 7. The mutant first appeared in B6C3Fe-a/a-hyh, a hybrid stock carrying the mutation hydrocephaly with hop gait. In the homozygous inbred jb/jb strain, a thinning of the rump hairs starts the moult at 14 to 15 days of age. By around 21 days of age, the body hair is completely lost up to a clear line on the head between the ears. The expression of jb may depend on one or more unlinked loci that are polymorphic among inbred strains.

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Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse

Article Abstract:

Mesenchymal dysplasia (mes) is an autosomal recessive mutation that results in abnormal growth in many mesoderm-derived tissues. The condition in mes mutation is similar to some human syndromes, and the mutation provides a mouse model for studies on connective tissue disorders. The mutation is mapped to chromosome 13, close to the genes that regulate growth. Mes mutation produces skeletal abnormalities, such as, preaxial polydactyly of all four feet, a shorter kinky tail, wide set eyes, and a shortened face.

Chromosomes, Animals, Mice as laboratory animals, House mouse

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