RuvAB acts at arrested replication forks

Article Abstract:

The mechanism of DNA double-stranded break (DSB) formation was examined by genetic means and by direct measure of the amount of in vivo linear DNA in Escherichia coli cells that lack the RecBCD recombination complex. The RuvABC proteins were found to be responsible for the occurrences of DSBs at arrested replication forks. RecBCD may act on the double-stranded tail prior to the cleavage of the RuvAB-bound junction by RuvC to rescue the blocked replication fork without breakage.

DNA, Genetic recombination

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Novel DNA polymerases offer clues to the molecular basis of mutagenesis

Article Abstract:

Advances in the characterization and identification of a number of DNA polymerases, with the prospect of even more bound to be discovered in the near future, have led to a greater understanding of several aspects of mutagenesis in both lower and higher organisms. These include the discovery of about 20 nonessential genes that comprise the so-called SOS system in E. coli. These SOS genes are known to be involved in spontaneous or DNA damage-induced mutagenesis.

DNA polymerases, Mutagenesis

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Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression

Article Abstract:

RNA polymerase modulation by (p)ppGpp, stringent response regulators, has shown a RecG-dependent mechanism for replication fork progression. Correlation between ability of Escherichia coli cells to survive DNA damage and ability to change RNA polymerase through the stringent response regulators has been found. It appears a general model in which recombination lies behind genome duplication exists despite frequent obstacles to replication fork progression.

United Kingdom, RNA polymerases, Cytogenetics

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