S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

Article Abstract:

Research has been conducted on Oct-1 coactivator OCA-S which is important for histone H2B transcription. The authors have investigated the functional identification and purification of OCA-S activity, and they report that the characterization of this cofactor has identified the role for the p38 subunit which is identical to glyceraldehyde-3-phosphate dehydrogenase, and that p38 mediates S phase-inducible H2B promoter activation.

All Other Basic Organic Chemical Manufacturing, CHEMICALS AND ALLIED PRODUCTS, Glycerine, Histones, Phosphates, Oxidoreductases, Glycerol, Aldehydes, Chemical inhibitors, Glycerin

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Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development

Article Abstract:

A study is presented to show that OCA-B also functions in the pre-B1-to-pre-B2 cell transition and most surprisingly, that it directly interacts with SYK. Combined with the deregulation of OCA-B target genes, this may explain the multitude of defects observed in B cell development and immune response of Oca-b mice.

Science & research, Research, B cells, Genetic research

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Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translation control

Article Abstract:

Research has been conducted on human ribosomal protein L13a. The authors describe the development of the model in which this protein functions both as protein synthesis machine and as a regulatory protein depot.

Protein synthesis, Ribosomal proteins

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