Sculpting the proteome with AAA+ proteases and disassembly machines

Article Abstract:

The machines of protein destruction-including energy-dependent proteases and disassembly chaperones of the AAA+ ATPase family-function in all kingdoms of life to sculpt the cellular proteome ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Enzymes of the AAA+ ATPase family play critical role in this sculpting of the proteome in all organisms.

Drugs, Cellular Protein, In-Vitro Diagnostic Substance Manufacturing, Cellular proteins, Proteomics

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ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans

Article Abstract:

The role of ubiquitin-conjugating enzyme (UBC)-18 and ARI-1, an Ariadnean ubiquitin-ligase in controlling the development of the pharynx in Caenorhabditis elegans is discussed.

United States, All Other Basic Organic Chemical Manufacturing, Enzymes for Food Processing, Developmental biology, Caenorhabditis elegans, Pharynx, Throat

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