Shiga toxin 2e-producing Escherichia coli isolates from humans and pigs differ in their virulence profiles and interactions with intestinal epithelial cells

Article Abstract:

The putative virulence genes in Shiga toxin (Stx)2e-producing Escherichia coli strains isolated from humans and diseased pigs are compared in order to assess the extent to which they are related. The results demonstrate that Escherichia coli isolates producing Shiga toxin 2e have imported specific virulence and fitness determinants, which allow them to adapt to the specific hosts in which they cause various forms of disease.

United States, Epithelial cells, Virulence (Microbiology)

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Presence and characterization of a mosaic genomic island which distinguishes sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H- from E. coli O157:H7

Article Abstract:

A mosaic genomic island comprising Shigella resistance locus (SRL) sequences flanked by segments of Escherichia coli O157:H7 strain EDL933 O islands were identified in sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H- strain 493/89. It was found that PCR targeting the SRL- related sequence is a useful tool to distinguish SF EHEC O157:H- from EHEC 0157:H7.

Genetic aspects, Drug resistance in microorganisms, Microbial drug resistance, Shigella

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Shiga toxin gene loss and transfer in vitro and in vivo during enterohemorrhagic Escherichia coli O26 infection in humans

Article Abstract:

The concept of interconversions between atypical enteropathogenic Escherichia coli (aEPEC) O26 and enterohemorrhagic Escherichia coli (EHEC) O26 involving loss and gain of Shiga toxins (Stx)-encoding bacteriophages is examined.

Bacterial toxins, Bacteriophages

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