Skeletal and CNS defects in Presenilin-1-deficient mice

Article Abstract:

The normal physiological role of the Presenilin-1 (PS1) was analyzed in PS1 homozygous mutant mice. Homozygous mutations in the PS1 gene in mice that were derived from four independent embryonic stem cell lines induced death after natural birth or caesarean-section. The PS1 homozygous mutant mice also exhibited gross skeletal and central nervous system abnormalities . Furthermore, brain abnormalities in the mutants was caused by reduced number of progenitor cells and neurons in the ventrolateral region of the ventricular zone.

Genetic aspects, Alzheimer's disease, Cell differentiation, Morphogenesis, Embryology, Animal embryology, Mice as laboratory animals, House mouse

---

T cell receptor delta gene mutant mice: independent generation of alpha-beta T cells and programmed rearrangements of gamma-delta TCR genes

Article Abstract:

Mutant mice deficient in gamma-delta T cell receptor (TCR) were generated to elucidate the molecular mechanisms of the expression of distinct subsets of gamma-delta T cells. The results showed that differential generation of gamma-delta T cell subsets involves an intracellular mechanism acting at the DNA rearrangement level. Furthermore, gamma-delta T cells are not required for the normal development of alpha-beta T cells.

T cell antigen receptors, T cells, Antibody diversity

---

Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC-gamma mutant mice

Article Abstract:

Mutant mice deficient in protein kinase C-gamma are unable to coordinate motor activity but learn discrete motion elements such as eyeblinking conditioning. Cerebellar long-term depression is unaffected in the mutants.The motor coordination defects are probably due to the presence of excess multiple climbing fibers in the Purkinje cells of the mutants.

Physiological aspects, Motor ability, Motor skills, Protein kinases

Similar abstracts:

• Abstracts: A clinical variant of neurofibromatosis type 1: familial spinal neurofibromatosis with a frameshift mutation in the NF1 (ital) gene
• Abstracts: Strategies for identification of mutations causing hereditary retinal diseases in dogs: evaluation of opsin as a candidate gene
• Abstracts: Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisae. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
• Abstracts: Evolution of the mouse H-2K region: a hot spot of mutation associated with genes transcribed in embryos and/or germ cells
• Abstracts: Human microsatellites applicable for analysis of genetic variation in apes and Old World monkeys. DNA fingerprinting in a butterfly, Bicyclus anynana (Satyridae)

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.