Squid hnRNP protein promotes apical cytoplasmic transport and localization of Drosophila pair-rule transcripts

Article Abstract:

A localization mechanism for pair-rule transcripts was discussed which utilizes a new mRNP injection assay. It was shown that synthetic, fluorescently tagged fushi tarazu transcripts' ability to localize is impaired after its injection into blastoderm embryos. On the other hand, it was observed that rapid and specific apical localization that is dependent on an intact microtubule cytoskeleton occurs with nuclear protein extracts preincubation.

Analysis, Physiological aspects, Growth, Drosophila, Cell organelles, Organelles, Squids, Squid

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MSX1 inhibits MyoD expression in fibroblast x 10T1/2 cell hybrids

Article Abstract:

A study shows that human MSX1 inhibits activation of MyoD expression in primary fibroblast x 10T1/2 cell hybrids and finds that chromosome 4, but not 8, inhibits myoD activation in 10T1/2 cell hybrids. Forced expression of Msx1 represses myoD enhancer activity. Msx1 proteins binds to the myoD enhancer and likely represses myoD transcription directly. However, antisense MSX1 relieves repression mediated by chromosome 4.

Chromosomes, Fibroblasts

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