Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice

Article Abstract:

Crystallins are lens-specific proteins and gamma-crystallins are important structurally in lens fiber cells of amphibians and mammals. Sox1, one of several transcription factors, directly regulates the gamma-crystallin genes. It is essential for mouse lens development. Without it, microphthalmia and cataract will occur; mutant lens fiber cells will not elongate without gamma-crystallins. The SOX1 protein interacts directly with a promoter element kept in gamma-crystallin genes and seems to be responsible for expression. Dominant inherited cataracts are related to the gene cluster for gamma-crystallins.

Cataract, Genetic regulation, Eye, Cataracts

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Combined ectopic expression of Pdx 1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue

Article Abstract:

Ectopic, pan-endodermal activation of Xptf1a/p48 during pancreas precursor cell stages of Xenopus embryogenesis results in an expansion of the pancreatic territory, precisely within the borders of X1Hbox8 expression. A study is presented to show that a combination of XPtf1a/p48 and X1Hbox8 is sufficient to convert nonpancreatic endodermal cells into pancreatic precursor cells.

United States, Science & research, Gene expression, Pancreas, Endoderm

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