Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2

Article Abstract:

Two splicing factors namely Ntr1 and Ntr2 that are involved in disassembly of the spliceosome are identified. Immunoprecipitation analysis of these reveals that Ntr1 and Ntr2 form a stable complex with DExD/H-box RNA helicase Prp43 in the splicing extract.

RNA, Genetic research

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Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome

Article Abstract:

Prp43 helicase activites of the splicing factor Ntr1 required for lariat-intron release from spliceosomes. Regulation of motor activity of a DEAH-box protein is important for mRNA splicing.

Genetic regulation, RNA splicing, Report, Helicases

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[Beta]-catenin is a Nek2 substrate involved in centrosome separation

Article Abstract:

The applications of [beta]-catenin in the interphase centrosomes are investigated. The [beta]-catenin is a Nek2 substrate, which is extremely useful in the centrosome separation.

Methods, Centrosomes, Centrosome, Chemical properties

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