Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

Article Abstract:

The carcinoma -associated fibroblasts (CAFs) extracted from human breast carcinomas promotes the growth of admixed breast carcinoma cells significantly more than normal mammary fibroblasts derived from the same patients. The demonstration showed that the fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1.

Neovascularization, Fibroblasts

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A lost generation

Article Abstract:

The funding policies of the National Institutes of Health (NIH) have made it very difficult for young researchers to procure research funds for basic biomedical research. The difficulties faced by the young researchers while obtaining their first R01 award from the NIH are discussed.

Government expenditures, Research and Development in the Physical, Engineering, and Life Sciences, Financial management, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Finance, United States. National Institutes of Health, Company financing, Medical research personnel, Medical researchers, Government finance, Medicine, Experimental

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

Article Abstract:

The transcription factor Twist plays an important role in metastasis. The molecular actions of Twist and its involvement in human breast cancer pathogenesis are characterized.

Genetic transcription, Transcription (Genetics), Morphogenesis

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