Structures of mismatch replication errors observed in a DNA Polymerase

Article Abstract:

Uncorrected DNA replication errors can cause mutations that are important for evolutionary processes leading to many diseases hence accurate DNA replication is important for genomic stability. Structural characterization of all twelve possible mismatches is presented and readings suggest that four mechanisms lead to mismatch-induces stalling of polymerase.

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Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-thomson syndrome

Article Abstract:

The Xenopus Laevis homolog (xRTS) of the human RECQL4 gene helicase mutated in Rothmund Thomson syndrome is implicated in the process of DNA replication. xRTs functions after pre-RC formation to promote loading of replication factors at origins, previously unrecognized activity necessary for initiation.

Protein binding

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Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2

Article Abstract:

Xenopus egg/oocyte system is used to examine the hypothesis that nutrient stores can regulate oocyte viability. It is suggested that exhaustion of oocyte nutrients, resulting in an inability to generate, may contribute to oocyte apoptosis.

Cell death, Metabolic regulation, Oocytes

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