Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus

Article Abstract:

Suppression of the Triplo-lethal locus (Tpl) in Drosophila melanogaster was found to be mediated by an unlinked locus found in the X-chromosome's 7E3-8A5 region. Several duplications of this locus, which was named Isis and of Tpl narrowed down the location of Isis and revealed that its suppression of the triplo-lethal phenotype of Tpl was not caused by position effects but is an asymmetric gene dosage effect. It was suggested that Isis inhibits the expression of the triplo-lethal phenotype of Tpl only indirectly.

Lethal mutation

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Effects of P elements on quantitative traits in Drosophila melanogaster

Article Abstract:

The homozygous and heterozygous effects of P element insertions on the third chromosomal lines of Drosophila melanogaster were investigated. Ninety-four third chromosome lines which contained on average 3.1 stable P element inserts were created by P element mutagenesis. Average homozygous viability was reduced by about 38% while heterozygous viability was reduced by 17%. The mutational variance for bristle traits per homozygous and heterozygous inserts for both sexes showed similar 0.03 environmental variance.

Translocation (Genetics)

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Nonsense suppression of the major rhodopsin gene of Drosophila

Article Abstract:

Nonsense mutations were introduced in the Leu-205 and Leu-309 positions of the Drosophila ninaE gene, which codes for rhodopsin. Analysis of genetic and natural nonsense suppression showed that the 205 mutation is more suppressible than the 309 mutation. Comparisons between the leucine-inserting tRNA nonsense suppressors DtL(a) and DtL(b) showed that the opal suppressor from DtL(a) tRNA gene is more efficient than either the amber or opal suppressors from DtL(b).

Rhodopsin

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