Susceptibility of calves to challenge with Salmonella typhimurium 4/74 and derivatives harbouring mutations in htrA or purE

Article Abstract:

Research reveals differences in the virulence of wild-type and mutant forms of Salmonella typhimurium in cattle and mice. Data demonstrate that while oral challenge of the wild-type is highly virulent, subcutaneous challenge is not in the cattle. Mutant forms are attenuated in mice but cattle and calves show susceptiblity.

Infection, Cattle, Calves, Calves (Animals)

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Intimin from enteropathogenic Escherichia coli mediates remodelling of the eukayotic cell surface

Article Abstract:

Research reveals that intimin is an enteropathogenic Escherichia coli adhesion molecule which along with its secreted proteins mediates attaching and effacing lesion by activating signal transduction pathways. Data further show that intimin is involved in the eukaryotic cell surface modification.

Mexico, Analysis, Cellular signal transduction, Epithelial cells, Molecular biology, Cell membranes, Plasma membranes, Cell adhesion, Surface chemistry

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Salmonella typhimurium thyA mutants fail to grow intracellularly in vitro and are attenuated in mice

Article Abstract:

Results demonstrate that the thymidylate synthase activity mutants of Salmonella typhimurium ATCC14028 are unable to grow intracellularly in macrophage-like cell lines and human epithelial cell lines and in culture. Data further indicate that the mutants show impaired virulence as well.

Switzerland, Bacterial growth, Thymidine

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